MovDisordV3, Main, Exploration, bibRecord, 003579

Association of α‐synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset

Identifieur interne : 003579 ( Main/Exploration ); précédent : 003578; suivant : 003580

Association of α‐synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset

Auteurs : Georgios M. Hadjigeorgiou [Grèce] ; Georgia Xiromerisiou [Grèce, États-Unis] ; Vanessa Gourbali [Grèce] ; Kostantinos Aggelakis [Grèce] ; Nikolaos Scarmeas [Grèce, États-Unis] ; Alexandros Papadimitriou [Grèce] ; Andrew Singleton [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-04.

RBID : ISTEX:A2A479C7024F1C08F6E97F1729979628BDDBD881

Descripteurs français

Pascal (Inist)
- Age apparition, Parkinson maladie, Polymorphisme, Système nerveux pathologie.
Wicri :
- geographic : Grèce.

English descriptors

KwdEn :
- Adult, Age of Onset, Age of onset, Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Chi-Square Distribution, Confidence Intervals, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Greece (ethnology), Humans, Male, Microsatellite Repeats (genetics), Middle Aged, Nervous system diseases, Odds Ratio, Parkinson Disease (genetics), Parkinson Disease (mortality), Parkinson disease, Parkinson's disease, Polymorphism, Polymorphism, Genetic, Promoter Regions, Genetic, Rep1, polymorphism, Survival Analysis, alpha-Synuclein (genetics), association study, α‐synuclein.
MESH :
- chemical , genetics : alpha-Synuclein.
- geographic , ethnology : Greece.
- genetics : Microsatellite Repeats, Parkinson Disease.
- mortality : Parkinson Disease.
- Adult, Age of Onset, Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Chi-Square Distribution, Confidence Intervals, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Genetic, Promoter Regions, Genetic, Survival Analysis.

Abstract

The α‐synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80–5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep1 allele 2 was earlier (3.6 years) compared to noncarriers (adjusted hazard ratio = 2.21; 95% CI = 1.58–3.10). Kaplan–Meier analysis also supported a dosage effect of Rep1 allele 2 on age at onset. For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/A2A479C7024F1C08F6E97F1729979628BDDBD881/fulltext/pdf

DOI: 10.1002/mds.20752

Affiliations:

Le document en format XML

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<author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
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<author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name>
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<author><name sortKey="Gourbali, Vanessa" sort="Gourbali, Vanessa" uniqKey="Gourbali V" first="Vanessa" last="Gourbali">Vanessa Gourbali</name>
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<author><name sortKey="Aggelakis, Kostantinos" sort="Aggelakis, Kostantinos" uniqKey="Aggelakis K" first="Kostantinos" last="Aggelakis">Kostantinos Aggelakis</name>
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<author><name sortKey="Scarmeas, Nikolaos" sort="Scarmeas, Nikolaos" uniqKey="Scarmeas N" first="Nikolaos" last="Scarmeas">Nikolaos Scarmeas</name>
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<author><name sortKey="Papadimitriou, Alexandros" sort="Papadimitriou, Alexandros" uniqKey="Papadimitriou A" first="Alexandros" last="Papadimitriou">Alexandros Papadimitriou</name>
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<author><name sortKey="Gourbali, Vanessa" sort="Gourbali, Vanessa" uniqKey="Gourbali V" first="Vanessa" last="Gourbali">Vanessa Gourbali</name>
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<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
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<pubPlace>Hoboken</pubPlace>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Age of onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Case-Control Studies</term>
<term>Chi-Square Distribution</term>
<term>Confidence Intervals</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Greece (ethnology)</term>
<term>Humans</term>
<term>Male</term>
<term>Microsatellite Repeats (genetics)</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Odds Ratio</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (mortality)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Polymorphism</term>
<term>Polymorphism, Genetic</term>
<term>Promoter Regions, Genetic</term>
<term>Rep1, polymorphism</term>
<term>Survival Analysis</term>
<term>alpha-Synuclein (genetics)</term>
<term>association study</term>
<term>α‐synuclein</term>
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</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Microsatellite Repeats</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Analysis of Variance</term>
<term>Case-Control Studies</term>
<term>Chi-Square Distribution</term>
<term>Confidence Intervals</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Polymorphism, Genetic</term>
<term>Promoter Regions, Genetic</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Age apparition</term>
<term>Parkinson maladie</term>
<term>Polymorphisme</term>
<term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">The α‐synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80–5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep1 allele 2 was earlier (3.6 years) compared to noncarriers (adjusted hazard ratio = 2.21; 95% CI = 1.58–3.10). Kaplan–Meier analysis also supported a dosage effect of Rep1 allele 2 on age at onset. For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD. © 2005 Movement Disorder Society</div>
</front>
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<li>États-Unis</li>
</country>
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<name sortKey="Aggelakis, Kostantinos" sort="Aggelakis, Kostantinos" uniqKey="Aggelakis K" first="Kostantinos" last="Aggelakis">Kostantinos Aggelakis</name>
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<name sortKey="Papadimitriou, Alexandros" sort="Papadimitriou, Alexandros" uniqKey="Papadimitriou A" first="Alexandros" last="Papadimitriou">Alexandros Papadimitriou</name>
<name sortKey="Scarmeas, Nikolaos" sort="Scarmeas, Nikolaos" uniqKey="Scarmeas N" first="Nikolaos" last="Scarmeas">Nikolaos Scarmeas</name>
<name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name>
</region>
<name sortKey="Scarmeas, Nikolaos" sort="Scarmeas, Nikolaos" uniqKey="Scarmeas N" first="Nikolaos" last="Scarmeas">Nikolaos Scarmeas</name>
<name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name>
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Movement Disorders (revue)

Association of α‐synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset

Association of α‐synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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